Kawasaki Disease Coronary Artery Z-Score & Risk Calculator (AHA 2024)

KD
Dr. Mridul Agarwal, MD, FNB (Pediatric Cardiology)
Senior Consultant, Pediatric & Fetal Cardiac Sciences | Sir Ganga Ram Hospital, New Delhi
Clinical Guideline: AHA 2024 Scientific Statement Update
Citation: Circulation. 2024;150:e481–e500 / 2025;151:e863

🩺 Kawasaki Disease Coronary Z-Score & Risk Calculator

AHA 2024 Guidelines

Compute BSA-adjusted coronary artery Z-scores (Boston McCrindle 2007 & Montreal Dallaire 2011), stratify AHA Risk Levels (1 through 5.4), calculate Son et al. & Kobayashi risk scores, and view tailored antithrombotic ladders and follow-up schedules.

Core Kawasaki Disease Clinical Principles (AHA 2024 / 2017)

Coronary Aneurysm Classification

No involvement: Z < 2
Dilation only: Z 2.0 to <2.5
Small aneurysm: Z 2.5 to <5.0
Medium aneurysm: Z 5.0 to <10.0 and absolute < 8 mm
Giant aneurysm: Z ≥ 10.0 or absolute ≥ 8.0 mm

Primary Therapy Intensification (High-Risk)

Patients with Age < 6 months, Baseline Z ≥ 2.5, or Son Risk Score ≥ 3 points are at high risk of CAA by 8 weeks and should receive dual anti-inflammatory therapy (IVIG 2 g/kg + Infliximab 10 mg/kg OR IVIG + Prednisolone RAISE taper).

Antithrombotic & DOAC Updates

Small CAAs require low-dose ASA alone. Medium CAAs receive DAPT (ASA + Clopidogrel). Giant CAAs require ASA + Systemic Anticoagulation (Warfarin INR 2–3, LMWH, or direct oral anticoagulants such as Apixaban or Edoxaban per 2024 statement).